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Title Development of a Clinical Research Method for the Measurement of Testosterone and Dihydrotestosterone
Summary T he wide variation in testosterone and DHT concentrations as well as the inherent difficulties in measuring these molecules, has made it difficult to develop test methods for them. To measure these molecules successfully by LC /MS requires an effective sample preparation method. Using an online S P E system greatly accelerated t he development of an LC / MS met hod by quic kly identifying and utilizing optimized S P E conditions for isolating these androgens from plasma samples.
Category 2. Symbiosis Application Notes

These are application notes that have been made in our application lab. They were based on customer demo's and customer method development requests. They include sorbent screening, a calibration curve and are optimized for carry over. They are not always (completely) validated
 
Matrix
Market OSM Clinical
Technique online SPE
Cartridge Waters MassTrak- C 8 OSM Cartridge
Detection Waters Mass Spectrometer: Xevo® TQ-S
Compounds DHT, Testosterone and Dihydrotestosterone
Compound Group Testosterone , steroid hormones
Sample_volume 200 µL
 
Contact Martijn van Faassen, Maarten van den Noort and Ido Kima
Account University Medical Center, Groningen, Netherlands
Published poster Technical Brief
Date 04.08.2015
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Remarks Testosterone is a steroid hormone from the androgen group and is the principal male sex hormone and an anabolic steroid

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Status published