| Detailed information | |
| Title | Development of a Clinical Research Method for the Measurement of Testosterone and Dihydrotestosterone |
| Summary | T he wide variation in testosterone and DHT concentrations as well as the inherent difficulties in measuring these molecules, has made it difficult to develop test methods for them. To measure these molecules successfully by LC /MS requires an effective sample preparation method. Using an online S P E system greatly accelerated t he development of an LC / MS met hod by quic kly identifying and utilizing optimized S P E conditions for isolating these androgens from plasma samples. |
| Category | 2. Symbiosis Application Notes These are application notes that have been made in our application lab. They were based on customer demo's and customer method development requests. They include sorbent screening, a calibration curve and are optimized for carry over. They are not always (completely) validated |
| Matrix | |
| Market | OSM Clinical |
| Technique | online SPE |
| Cartridge | Waters MassTrak- C 8 OSM Cartridge |
| Detection | Waters Mass Spectrometer: Xevo® TQ-S |
| Compounds | DHT, Testosterone and Dihydrotestosterone |
| Compound Group | Testosterone , steroid hormones |
| Sample_volume | 200 µL |
| Contact | Martijn van Faassen, Maarten van den Noort and Ido Kima |
| Account | University Medical Center, Groningen, Netherlands |
| Published | poster Technical Brief |
| Date | 04.08.2015 |
| Read PDF document | |
| Remarks | Testosterone is a steroid hormone from the androgen group and is the principal male sex hormone and an anabolic steroid |
| Users | |
| Status | published |