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Title Therapeutic Drug Monitoring Using Direct Flow-Through Elution from Dried Blood Spots Together with Fast LC-TOF-MS
Summary We demonstrate quantitation of a therapeutic drug in blood from dried blood spots (DBS) with direct flow-through LC-MS, including an examination of extraction methods, varied hematocrit levels, matrix effects and interferences.
Category 1. Prospekt 1 Application information

These applications were mostly done on Prospekt1 and can offer a good starting point when executed on Symbiosis. Care should be taken on differences in volume (SDU vs. HPD). Also, most information is based on other detectors than MS
 
Matrix blood
Market Clinical
Technique DBS
Cartridge 2 x 10 mm 7 μm HySphere C18 HD
Detection PerkinElmer AxION 2 TOF mass spectrometer
Compounds Nortriptyline, Pamelor
Compound Group drug, ADHD, antidepressant
Sample_volume 20 µL
 
Contact Robert J. Seward, Jonathan Wilson, Dhvani Shah, Catherine Stacey
Account PerkinElmer, Inc., 940 Winter Street, Waltham, MA USA (800) 762-4000 or (+1) 203 925-4602 www.perkinelmer.com
Published poster
Date 10.12.2019
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Status poster