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Title DETERMINATION OF EMERGING ORGANIC POLLUTANTS IN WASTEWATER BY "ON-LINE SPE" LC/QqLIT AND IDENTIFICATION BY MS/MS SPECTRUM
Summary Last years have been growing the interest in the quantitation of pharmaceuticals and drugs, called Emerging Organic Contaminants (EOPs), in drinking water or wastewater, in order to control the presence of these compounds and to avoid future problems on the people. LC/MS is the appropriate technique because of the selectivity, good sensitivity, linearity and robustness. Problems had begun when confirmation of target compounds must to be done and identification of unknown compounds is also needed. Mainly at very low concentrations, MRM ratios are not so consistent for confirmation. Hybrid QTrap MS/MS (QqLIT) systems allow to do that confirmation issues. "On-Line SPE" offer several features to improve the performance of the method: less sample volume, less timework required, better recoveries. Only 1 ml sample is needed to achieve the detection limit required.
Category 2. Symbiosis Application Notes

These are application notes that have been made in our application lab. They were based on customer demo's and customer method development requests. They include sorbent screening, a calibration curve and are optimized for carry over. They are not always (completely) validated
 
Matrix Wastewater, water
Market Food, Environmental
Technique online SPE
Cartridge HySphere Resin GP (10x2mm)
Detection AB Sciex API 3200QTRAP
Compounds Sotalol Timolol, Atorvastatin o-Hydroxyatorvastatin p-Hydroxyatorvastatin Simvastatin Simvastatin hydroxy acid Betamethasone Budesonide Cortisone Dexamethasone Diethylsilbestrol Hydrocortisone Prednisolone Prednisone PFBS PFOA PFQS Bisphenol A Bezafibrate Gemfibrozil Clofibric acid Gemfibrozil Enalapril Acetaminophen Diazepam Meprobamate Amoxicillin Carbadox Chloramphenicol Chlorotetracycline Ciprofloxacin Doxycycline Enrofloxacin Erythromycin Lasalocid A Lincomycin Meclocycline Monensin sodium Norfloxacin Oxytetracline Penicillin G Roxithromycin Sulfachloropyridazine Sulfadiazine sodium Sulfadimethoxine Sulfamerazine Sulfamethazine Sulfamethizole Sulfamethoxazole Sulfathiazole Tetracycline Triclosan Trimethoprim Tylosin Virginiamycin M1 Warfarin Fluoxetine Norfluoxetine Carbamazepine Dilantin Diclofenac Flunisolide Fluocinolone acetonide Ibuprofen Indomethacin Ketoprofen Naproxen Triamcinolone Triamcinolone acetonide Gemfibrozil Atrazine Linuron 17-a-Ethynyl Estradiol 17-ß-Estradiol 19-Norethersterone Equilin Esterone Estriol Progesterone 6-acetylmorphine Acetylcodeine Amphetamine Cocaethylene Cocaine Codeine EDDP Ephedrine Heroin LSD MDMA Methadone Methamphetamine Morphine Nor-LSD Nor-THC Risperidone Acebutolol Alprenolol Atenolol Bisoprolol Metoprolol Nadolol Pindolol Propranolol OH-LSD OH-THC THC Delta-9-THC Benzoylecgonine Morphine3-a-D-glucuron Morphine 6-a-D-glucuron THC-COOH Caffeine
Compound Group ACE inhibitor, Analgesic, Antibiotics, Anticoagulant, Antidepressive, Anti-epileptic, Anti-inflammatory, Beta-blocker, Chloresterol reducer, Corticoid, Hormone, Fibrate drug, Illicit drug.
Sample_volume 1 mL
 
Contact N. Bellós, L. Bonetto, J.F. Rodriquez, F.A. Mocholi
Account SAILab, Argentes, S ED I bD, 08290 Barcelona, Spain.
Published
Date 03.11.2011
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Remarks This job shows a very rapid and effective method using all the most of the features of a QqLIT system to get very good sensitivity and identification capabilities. Using MRM transition to quantitate and MS/MS spectrum obtained with the Linear Ion Trap for identification purposes is possible to work with a low resolution system and found unknown compounds from a pre-target list.

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