| Detailed information | |
| Title | A new sample introduction technique for mass spectrometry that allows for dried blood spot analysis and online SPE |
| Summary | Blood samples were directly flushed from the paper towards a SPE cartridge and sufficient clean-up was obtained to measure Propranolol, Haloperidol, Amitriptyline and Verapamil by means of MS/MS without the need of an LC separation. The new DBS-SPE-MS/MS methodology can also be considered as DBS-LC-MS/MS with a disposable mini LC column and additional clean-up tools. |
| Category | 1. Prospekt 1 Application information These applications were mostly done on Prospekt1 and can offer a good starting point when executed on Symbiosis. Care should be taken on differences in volume (SDU vs. HPD). Also, most information is based on other detectors than MS |
| Matrix | blood |
| Market | clinical |
| Technique | DBS |
| Cartridge | HySphere C18HD 10x2 mm |
| Detection | ESI-MS (API4000, Applied Biosystems) |
| Compounds | Propranolol, Haloperidol, Amitriptyline, Verapamil |
| Compound Group | beta blocker, Inderal, Haldol, antipsychotic, tricyclic antidepressant, Elavil, Verapamilhydrochlorid, class-IV antiarrhythmic |
| Sample_volume | 15 µL |
| Contact | Lena Khadnevich and Emile Koster |
| Account | Spark Holland, Pieter de Keyserstraat 8, 7800AJ, Emmen, The Netherlands, Phone (+31) 591 631 700, E-mail: emile.koster@sparkholland.com, Website: www.sparkholland.com |
| Published | poster |
| Date | 10.12.2019 |
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| Users | |
| Status | poster |