| Detailed information | |
| Title | Monitoring Opioid Use for Pain Management Using a Fully Automated DBS-SPE-LC/MS/MS Approach |
| Summary | An automated DBS-SPE-LC/MS/MS method for the quantitation of four representative opioids in whole blood was developed and validated over the concentration range of 1 to 500 ng/mL blood, allowing detection of subtherapeutic, therapeutic, and toxic levels. |
| Category | 1. Prospekt 1 Application information These applications were mostly done on Prospekt1 and can offer a good starting point when executed on Symbiosis. Care should be taken on differences in volume (SDU vs. HPD). Also, most information is based on other detectors than MS |
| Matrix | blood |
| Market | Clinical |
| Technique | DBS |
| Cartridge | HySphere C18 HD, 7 μm, 2 x 10 mm (Spark-Holland) |
| Detection | LCMS-8050 mass spectrometer (Shimadzu) |
| Compounds | morphine, codeine, oxycodone, hydrocodone |
| Compound Group | opioids, drugs |
| Sample_volume | 10 µL |
| Contact | Ruth Verplaetse and Jack Henion |
| Account | Quintiles, 19 Brown Road, Ithaca, New York |
| Published | poster |
| Date | 10.12.2019 |
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| Remarks | |
| Users | |
| Status | poster |