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Detailed information
Title Monitoring Opioid Use for Pain Management Using a Fully Automated DBS-SPE-LC/MS/MS Approach
Summary An automated DBS-SPE-LC/MS/MS method for the quantitation of four representative opioids in whole blood was developed and validated over the concentration range of 1 to 500 ng/mL blood, allowing detection of subtherapeutic, therapeutic, and toxic levels.
Category 1. Prospekt 1 Application information

These applications were mostly done on Prospekt1 and can offer a good starting point when executed on Symbiosis. Care should be taken on differences in volume (SDU vs. HPD). Also, most information is based on other detectors than MS
 
Matrix blood
Market Clinical
Technique DBS
Cartridge HySphere C18 HD, 7 μm, 2 x 10 mm (Spark-Holland)
Detection LCMS-8050 mass spectrometer (Shimadzu)
Compounds morphine, codeine, oxycodone, hydrocodone
Compound Group opioids, drugs
Sample_volume 10 µL
 
Contact Ruth Verplaetse and Jack Henion
Account Quintiles, 19 Brown Road, Ithaca, New York
Published poster
Date 10.12.2019
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Status poster