| Detailed information | |
| Title | Dried blood spot sampling for therapeutic drug monitoring of pazopanib |
| Summary | This study shows a good agreement between pazopanib levels measured in plasma and calculated plasma concentrations based on DBS sample collection • DBS could therefore be a very useful and patient friendly approach to monitor pazopanib therapy |
| Category | 1. Prospekt 1 Application information These applications were mostly done on Prospekt1 and can offer a good starting point when executed on Symbiosis. Care should be taken on differences in volume (SDU vs. HPD). Also, most information is based on other detectors than MS |
| Matrix | Blood |
| Market | Clinical |
| Technique | DBS |
| Cartridge | |
| Detection | validated LC-MS/MS method |
| Compounds | Pazopanid |
| Compound Group | Votrient, tyrosine kinase inhibitor, metastatic renal cell carcinoma, metastatic soft tissue sarcome |
| Sample_volume | 15 µL |
| Contact | Djoeke de Wit, Jan den Hartigh, Hans Gelderblom, Yanwen Qian, Margret den Hollander, Henk Verheul, Henk-Jan Guchelaar and Nielka P. van Erp |
| Account | Departments of Clinical Pharmacy & Toxicology and Medical Oncology, Leiden University Medical Center, Leiden |
| Published | poster |
| Date | 19.11.2019 |
| Read PDF document | |
| Remarks | |
| Users | |
| Status | poster |