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Detailed information
Title Dried blood spot sampling for therapeutic drug monitoring of pazopanib
Summary This study shows a good agreement between pazopanib levels measured in plasma and calculated plasma concentrations based on DBS sample collection • DBS could therefore be a very useful and patient friendly approach to monitor pazopanib therapy
Category 1. Prospekt 1 Application information

These applications were mostly done on Prospekt1 and can offer a good starting point when executed on Symbiosis. Care should be taken on differences in volume (SDU vs. HPD). Also, most information is based on other detectors than MS
Matrix Blood
Market Clinical
Technique DBS
Detection validated LC-MS/MS method
Compounds Pazopanid
Compound Group Votrient, tyrosine kinase inhibitor, metastatic renal cell carcinoma, metastatic soft tissue sarcome
Sample_volume 15 µL
Contact Djoeke de Wit, Jan den Hartigh, Hans Gelderblom, Yanwen Qian, Margret den Hollander, Henk Verheul, Henk-Jan Guchelaar and Nielka P. van Erp
Account Departments of Clinical Pharmacy & Toxicology and Medical Oncology, Leiden University Medical Center, Leiden
Published poster
Date 19.11.2019
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Status poster