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Detailed information
Title Quantitation of opioids in whole blood using fully automated DBS desorption coupled to on-line SPE-LC-MS/MS
Summary Excellent sensitivity of LC-MS/MS system (sub-pgamounts on column) makes quantitation of analytesin micro samples possible. We demonstrated the feasibility of a fully automated approach that combines › simple point-of-care sample collection (DBS) › on-line sample preparation (SPE) › sensitive and selective detection (LC-MS/MS) • Quantitation of subtherapeutic, therapeutic and toxic levels of opioids in DBS, within less than 5 minutes.
Category 1. Prospekt 1 Application information

These applications were mostly done on Prospekt1 and can offer a good starting point when executed on Symbiosis. Care should be taken on differences in volume (SDU vs. HPD). Also, most information is based on other detectors than MS
Matrix Blood
Market Clinical
Technique DBS
Cartridge C18
Detection LCMS 8050 (Shimadzu)
Compounds fentanyl, hydrocodone, oxycodone, codeine, morphine
Compound Group opioids, opiates, painkiller, drugs
Sample_volume 10 µL
Contact Ruth Verplaetseand Jack Henion
Account Q2 Solutions, Morrisville, USA
Published presentation
Date 19.11.2019
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