| Detailed information | |
| Title | The determination of ketoprofen in human whole blood using dried blood spot sampling and LC-MS/MS analysis |
| Summary | The objective of this work was: (i) to develop a dried blot spot (dbs) sampling method for ketoprofen, (ii) to develop a sensitive and selective bioanalytical LC-MS/MS method for the determination of ketoprofen in whole blood and in dried blood spots, (iii) to compare these methods with a previously validated method in human plasma, and (iv) to apply the method to monitor the ketoprofen concentrations in a pharmacokinetic study. |
| Category | 1. Prospekt 1 Application information These applications were mostly done on Prospekt1 and can offer a good starting point when executed on Symbiosis. Care should be taken on differences in volume (SDU vs. HPD). Also, most information is based on other detectors than MS |
| Matrix | Blood |
| Market | Clinical |
| Technique | DBS |
| Cartridge | |
| Detection | API3000 LC-MS/MS system (SCIEX) |
| Compounds | Ketoprofen |
| Compound Group | anti-inflammatory drug |
| Sample_volume | 30 µL |
| Contact | E. Mallat, M.J. Dröge, R. Wessel, F. Oostebring, H. Rutgers, K. de Jonge, E. Oosting |
| Account | Analytisch Biochemisch Laboratorium BV W.A. Scholtenstraat 7 9403 AJ Assen The Netherlands |
| Published | poster |
| Date | 19.11.2019 |
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| Remarks | |
| Users | |
| Status | poster |